Na Eprel 15, 2022, emechara nrụpụta pilot nke Lecardipine hydrochloride isi mgbanaka n'otu oge, ikike nrụpụta ugbu a bụ 5Mt / ọnwa.
Aha Bekee:Lercanidipine hydrochloride
Aha kemịkalụ:1,4-Dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylic acid 2-[(3,3-di phenylpropyl) methylamino] -l, l-dimethylethyl methyl ester hydrochloride.
Nọmba CAS: 132866-11-6
Ngwa:Maka ọgwụgwọ nke ọgwụ Lecardipine hydrochloride, ọ gaghị enwe mmetụta ọjọọ na glucose ọbara na ọkwa lipid, ma nwee mmetụta antihypertensive siri ike.
Atụmanya ahịa:
Enwere ihe karịrị nde mmadụ 200 na-arịa ọbara mgbali elu na China, enwerekwa nde 10 ndị ọrịa na-arịa ọbara mgbali elu kwa afọ, ọtụtụ n'ime ha anaghị achịkwa, na-ebute nnukwu nsogbu ọbara mgbali elu dị ka ọrịa strok, na ọnwụ kwa afọ na China n'etiti 3. nde ndị ọrịa nwere ọrịa obi, 50% metụtara ọbara mgbali elu, na ọnụ ahịa ọgwụgwọ ọrịa obi kwa afọ bụ ijeri yuan 309.8.Ihe kpatara njikwa adịghị mma abụghị naanị na ndị ọrịa maara banyere ọbara mgbali elu na nsogbu ya kwesịrị imeziwanye, kamakwa na ọtụtụ ndị ọrịa na-achọ ịṅụ ọgwụ ogologo ndụ na-adịghị mma na enweghị ike ịṅụ ọgwụ kwa ụbọchị, Otú ọ dị, nke a na-egosikwa na ndị ọrịa na-aṅụ ọgwụ ogologo oge. ahịa ọgwụ antihypertensive nwere ike ịgbasa.E jiri ya tụnyere ọgwụ ndị yiri ya, locarbodipine hydrochloride nwere nhọrọ vaskụla siri ike.Ngwongwo lipophilic ya pụrụ iche na-eme ka ọ dị ngwa ma na-adịgide adịgide antihypertensive mmetụta mmetụta atherogenic, karịsịa maka ndị ọrịa ọbara mgbali elu nwere atherosclerosis, nwere uru ngwa ụlọ ọgwụ dị elu yana atụmanya ahịa sara mbara.
Omume ọgwụ:
Lecardipine bụ ọgbọ ọhụrụ nke dihydropyridine calcium chanel hysteresis, nwere ike vaskụla vaskụla, mmetụta dị nro, mmetụta antihypertensive siri ike, ogologo oge ime ihe, mmetụta inotropic na-adịghị mma na ndị ọzọ.Nnyocha ọmụmụ vitro achọpụtala na locarbodipine na-enwe mmetụta izu ike kpọmkwem na akwara dị nro nke vaskụla, ya mere ọ nwere mmetụta antihypertensive siri ike na vivo, mana ọ nwere mmetụta dị nta na ọnụọgụ obi na mmepụta obi.N'ihi nnukwu mkpụrụ ndụ hydrophobic ya na solubility lipid siri ike, a na-ekesa locarbodipine ngwa ngwa na anụ ahụ na akụkụ ahụ mgbe ọ banyere n'ime ahụ, na-ejikọta ya na akpụkpọ anụ ahụ dị nro nke vaskụla, ma na-ahapụ nwayọọ nwayọọ.Ya mere, ọ bụ ezie na serum nke ọgwụ a nwere obere oge mkpochapụ nke ọkara ọdịda, mmetụta ya na-adịte aka.
Oge nzipu: Eprel-15-2022